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Mast Cell Disorder: Causes, Symptoms, Treatment22 Mar 2017 What is Mast Cell Activation Syndrome? Mast cell activation syndrome is a complex condition but one that is becoming more well-known. Mast cell activation syndrome (MCAS) involves many different body systems which can cause many different symptoms. Many of the symptoms are related to the cardiovascular, gastrointestinal, respiratory, and neurological systems as well [...]