Interstitial Cystitis and the Histamine Connection

Living with bladder pain and the constant urge ‘to go’ can be rather frustrating. Yet, you are certainly not alone. Interstitial cystitis, a chronic bladder syndrome affects millions of people, mostly women, every day. 

The good news is that you don’t have to struggle any longer. You can reduce your symptoms and recover from interstitial cystitis naturally following some simple steps.

In this article, you will learn what interstitial cystitis is and learn about its symptoms. I will explain what histamine intolerance is and why it may be the root cause of your bladder problem. I will share my natural interstitial cystitis recovery protocol, The 4-Phase Histamine Reset Plan along with proper supplementation.

What Is Interstitial Cystitis

You might have heard of interstitial cystitis being referred to as chronic pelvic pain (CPP), painful bladder syndrome (PBS), or bladder pain syndrome (BPS). It is a chronic bladder condition that affects between 4 to 12 million people in the United States. While it mostly affects women, it may occur in anyone regardless of gender, age, race, or ethnicity. 

Interstitial cystitis causes bladder pain or pressure, pelvic pain, increased frequency in urination, or an urgency to urinate. Its severity may range from mild to severe. Needless to say, interstitial cystitis can be a rather uncomfortable condition that may have a very serious impact on the quality of your life (1, 2, 3).

Symptoms of Interstitial Cystitis

The severity of symptoms varies from person to person. You may even experience symptom-free periods.

Symptoms of interstitial cystitis may include:

  • Pain in the pelvis 
  • Pain in the vulva or vagina
  • Pain between the vagina and anus in women and between the scrotum and anus in men
  • Pain in the lower abdomen or lower back
  • Chronic pelvic pain
  • Pain similar to a urinary tract infection but without an infection
  • Frequent urination, up to 60 times a day, usually only in small amounts
  • Persistent, urgent need to urinate
  • Pain when the bladder is full and relief after emptying the bladder
  • Painful sexual intercourse

Histamine Intolerance and Interstitial Cystitis

You may be surprised to hear that the root cause of your interstitial cystitis has nothing to do with your bladder and much more to do with histamine. Let’s learn more about histamine intolerance and how it’s connected to interstitial cystitis.

What Is Histamine?

Histamine is a chemical in your body that is responsible for a variety of functions. Its main role is to help your body get rid of allergens as part of your immune response. This is why people commonly take antihistamines for allergy-symptom relief. Histamine also communicates with your brain and triggers stomach acid release to aid digestion affecting your entire body.

What Is Histamine Intolerance?

Histamine becomes a problem when it builds up in your body. Histamine intolerance is basically an indication that your body has too much histamine. As a natural part of your immune response, your body sends enzymes to break down histamine in order to prevent too much build-up. However, when there is too much histamine, it becomes difficult to break it down and to metabolize it. 

Too much histamine can affect all parts of your body, including your gut, brain, lungs and cardiovascular system. It may lead to a list of unwanted symptoms, including skin problems, red eyes, low blood pressure, fast heart rate, anxiety, hormonal issues, headaches, seasonal allergies, digestive issues, sleep disturbances, bladder problems, and more. You can learn more about histamine intolerance, its symptoms, causes, and treatment options, in this article (4).

Histamine Intolerance and Interstitial Cystitis

Interstitial cystitis is one of the many health conditions linked to histamine intolerance. Research has found that people with interstitial cystitis have elevated mast-cell derived histamine levels and mast cell counts. One study of 33 women with interstitial cystitis has shown elevated histamine levels and the presence of a histamine producing bacteria in its participants. Another study found antihistamine therapy potentially beneficial for interstitial cystitis symptoms, suggesting that histamine intolerance is the root cause of the problem (5, 6, 7).

Natural Solutions for Interstitial Cystitis

Traditional treatment of interstitial cystitis may involve wearing loose clothing, bladder training, physical therapy, non-steroidal anti-inflammatory drugs, antihistamines, tricyclic antidepressants, pentosan polysulfate sodium medication, nerve stimulation, prescription medication dimethyl sulfoxide instilled into the bladder, and surgery. Common alternative therapies include acupuncture and guided imagery. However, none of these options alone address the root cause of interstitial cystitis, instead, some (like the meds) mask your symptoms & others (like physical therapy & accupuncture) can be a great compliment to the plan below to get you to full recovery.

Most of you can resolve your interstitial cystitis naturally by following The 4-Phase Histamine Reset Plan and supporting your body with HistoRelief, an immune-boosting supplement.

The 4-Phase Histamine Reset Plan

The most important part of treating histamine intolerance and interstitial cystitis is to treat the root cause of the problem. The 4-Phase Histamine Reset Plan does exactly that. 

Here is a quick overview of this simple yet life-changing protocol:

  • Phase 1 — Eliminate: During the first phase, I recommend that you remove all inflammatory and histamine foods from your diet for one to three months, as well as eliminate toxic personal care and cleaning products. Instead, consider a low-inflammatory, low-histamine diet and organic, natural, or homemade products
  • Phase 2 — Support the Liver: Your liver is an important detoxifying organ. However, having too much histamine can cause liver enzyme changes and liver dysfunction compromising your entire health. This is why I recommend you support your liver with a variety of strategies that I go over in my book, The 4-Phase Histamine Reset Plan: Getting to the Root of Migraines, Eczema, Vertigo, Allergies and More (8, 9).
  • Phase 3 — Go Deeper: Most of our modern-day chronic health issues, including histamine intolerance and interstitial cystitis are rooted in the gut. I recommend that you get tested for gut infections and nutritional deficiencies and support your gut through proper nutrition, lifestyle, and supplementation.
  • Phase 4 — Reintroduce: During the last phase of The 4-Phase Histamine Reset Plan, you can re-introduce some histamine foods. Since this reintroduction phase is very specific, it is critical that you follow my advice in The 4-Phase Histamine Reset Plan.

Read and Follow The 4-Phase Histamine Reset Plan

The 4-Phase Histamine Reset Plan is a simple yet refined system that helps you to overcome health issues related to histamine intolerance, including interstitial cystitis. It is important that you understand and follow each step properly. 

To guide you on your recovery journey, I recommend that you read my new book, The 4-Phase Histamine Reset Plan: Getting to the Root of Migraines, Eczema, Vertigo, Allergies and More where I talk about histamine intolerance and each phase of the plan in detail. Reading this book, you will understand everything from causes to solutions, testing to supplementation, diet to lifestyle to overcome histamine intolerance.

Pick up a copy, today to learn more about the plan and my recommendations. The book is full of nutritious and delicious recipes that will nourish your body during and after your recovery from interstitial cystitis.

HistoRelief for Histamine Intolerance

To support your recovery and to alleviate the symptoms of interstitial cystitis, I recommend HistoRelief. This supplement is a synergistic blend of nutrients that provides natural support to balance your immune response. This blend features, Tinofend®, a patented and clinically researched extract derived from the plant Tinospora cordifolia, which has a powerful ability to support immune regulation and immune response. As a result, it boosts your body’s ability to fight interstitial cystitis symptoms.

HistoRelief also includes quercetin, nettle leaf, vitamin C, and bicarbonate salts. Quercetin is a powerful bioflavonoid with anti-inflammatory and antioxidant properties that naturally inhibits histamine release. Research has shown that supplementing with quercetin may help to decrease pain in those with interstitial cystitis. Bicarbonate salts also help to maintain normal histamine metabolism, while nettle leaf and vitamin C further boost your immune system and are often recommended to fight interstitial cystitis (10, 11, 12).

Final Thoughts

Interstitial cystitis is an uncomfortable chronic bladder condition that involves pain and frequent or urgent urination. While it affects millions of people, it is possible to treat it naturally. Follow The 4-Phase Histamine Reset Plan and try HistoRelief to free yourself from the discomfort of interstitial cystitis and to reclaim your health and happiness.

If you are dealing with interstitial cystitis or suspect that you have histamine intolerance, I invite you to schedule a consultation with me. I can help to identify the root cause of your condition and recommend a personalized treatment plan to repair your body and regain your health and well-being. You may schedule your consultation here.

1. Conquering IC. Interstitial Cystitis Association. Link Here
2. Interstitial Cystitis. Mayo Clinic. Link Here
3. What Is Interstitial Cystitis (IC)? Centers for Disease Control and Prevention. Link Here
4. Maintz L, Novak N, Histamine and histamine intolerance, The American Journal of Clinical Nutrition, Volume 85, Issue 5, May 2007, Pages 1185–1196. Link Here
5. Heßdörfer E. Painful bladder syndrome/Interstitial cystitis and histamine intolerance – is there a link?  Bladder Centre Westend, Berlin, Germany. Link Here
6. Shan H, Zhang EW, Zhang P, Zhang XD, Zhang N, Du P, Yang Y. Differential expression of histamine receptors in the bladder wall tissues of patients with bladder pain syndrome/interstitial cystitis – significance in the responsiveness to antihistamine treatment and disease symptoms. BMC Urol. 2019 Nov 12;19(1):115. doi: 10.1186/s12894-019-0548-3. PMID: 31718622
7. Rudick CN, Bryce PJ, Guichelaar LA, Berry RE, Klumpp DJ. Mast cell-derived histamine mediates cystitis pain. PLoS One. 2008 May 7;3(5):e2096. doi: 10.1371/journal.pone.0002096. PMID: 18461160
8. How does the liver work? Institute for Quality and Efficiency in Health Care (IQWiG). Link Here
9. Balaban YH, Aka C, Koca-Caliska U. World J Hepatol. 2017 Jun 18; 9(17): 757–770. PMID: 28660010
10. Whitmore KE. Complementary and alternative therapies as treatment approaches for interstitial cystitis. Rev Urol. 2002;4 Suppl 1(Suppl 1):S28-35. PMID: 16986031
11. Histamine intolerance. Vickerstaff Health Services. Link Here
12. Supplements. Interstitial Cystitis Association. Link Here




Hi, I am Dr. Becky Campbell. I work with men and women who’ve had a health set back and are willing to do whatever it takes to reach optimal health so they can perform their best in their careers and be fully present with their family again.

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