The Histamine-PCOS Connection

Did you know that there is a strong histamine-PCOS connection? If you have PCOS, you are all too familiar with irregular periods, hair loss, ovarian cysts, weight gain, and other symptoms. What you may not know is that if you have PCOS, you may also have histamine intolerance. The good news is that once you understand the connection between histamine and PCOS, you can start taking appropriate steps to regain your health naturally.

In this article, you will learn about PCOS. You will understand how histamine intolerance and PCOS are linked. I will also share the top natural strategies to improve histamine intolerance and PCOS.

What Is PCOS?

Polycystic ovarian syndrome (PCOS) is a common hormonal disorder that affects about 5 million women of reproductive age in the US alone. Women with PCOS have excess levels of the androgen male hormone. Their ovaries tend to have small cysts that lead to hormonal imbalance and are unable to release eggs regularly. As a result, women with PCOS experience irregular, infrequent, or prolong menstrual cycles.

PCOS is the most common known cause of female infertility. PCOS also increases the risk of miscarriage, premature delivery, gestational diabetes, and pregnancy-induced high blood pressure. Besides menstrual irregularities, fertility issues, and pregnancy complications, PCOS also increases the risk of type 2 diabetes, high blood pressure, high cholesterol, sleep apnea, depression, anxiety, heart disease, and stroke (1, 2, 3, 4, 5).

Common symptoms of PCOS include (3, 5):

  • Missed, irregular, or light periods
  • Large ovaries
  • Ovaries with many cysts
  • Excess body hair, including on the stomach, chest, and back
  • Weight gain, especially belly fat
  • Acne or oily skin
  • Thinning hair 
  • Infertility
  • Skin tags on the neck or armpits
  • Dark or thick skin patches in the armpits, on the back of the neck, or under the breasts


The Histamine-PCOS Connection

When it comes to PCOS treatment and prevention, it is critical that we address both hormonal issues and related histamine intolerance. 

What Is Histamine Intolerance?

Histamine is a chemical that is responsible for a variety of functions in your body, including getting rid of allergens as part of your immune response, communicating with your brain, and triggering stomach acid release to aid digestion. Histamine intolerance means that you have too much histamine which can lead to various health issues.

As a natural part of your immune response, your body releases enzymes to break down histamine build-up. If you have too much histamine, your body won’t be able to keep up and won’t be able to break down the excess histamine properly. Histamine intolerance affects your entire body, including your gut, brain, lungs, cardiovascular system, and hormonal health. Histamine intolerance can manifest in a variety of ways, including hormonal issues, headaches, skin problems, digestive issues, sleep disturbances, bladder problems, anxiety, fast heart rate, seasonal allergies and more. Let’s see how histamine intolerance is linked to PCOS (6).

Histamine Intolerance and PCOS

Hormonal imbalances are one of the main causes of histamine intolerance. Estrogen dominance happens when estrogen and progesterone get out of balance and you end up with too much estrogen. Estrogen dominance plays a key role in the development and symptoms of PCOS and other conditions, including premenstrual syndrome (PMS), uterine fibroids, and breast cancer (7)

Women who have PCOS also tend to have low progesterone levels. This is not surprising since progesterone is critical for ovulation and most women with PCOS don’t ovulate consistently. Progesterone is not only essential for your period and reproduction, but it also supports the diamine oxidase (DAO) enzyme function. The DAO enzyme is essential for breaking down histamine in your food and excess histamine in your body. If your body is not producing sufficient progesterone, it cannot support the DAO enzyme function as well and will be unable to break down excess histamine efficiently either.

Another problem is that estrogen triggers the production of histamine from the mast cells in your ovaries and uterus. If you have too much estrogen, it means that your body has to make and release more histamine feeding the never-ending cycle of estrogen and histamine excess.

This estrogen-histamine connection is one of the reasons behind your PCOS symptoms. Estrogen dominance may increase PMS symptoms and may also cause bloating, gut issues, headaches, fatigue, insomnia, or irritability during the first part of your cycle or during ovulation when estrogen levels are higher.


Natural Solutions

If you have PCOS and histamine intolerance and want to improve your health naturally, I have some simple natural solutions for you. This is what I recommend to my patients with PCOS:

Follow The 4-Phase Histamine Reset Plan

To improve histamine intolerance and reduce your PCOS symptoms, it is important that you eat an anti-inflammatory, nutrient-dense, and low-histamine diet. I recommend that you eliminate histamine foods for one to three months, then slowly re-introduce them one by one following The 4-Phase Histamine Reset Plan. Along with dietary changes, it’s important that you eliminate toxic personal care and cleaning products as well and instead use organic, natural, or homemade products

The 4-Phase Histamine Reset Plan is a plan that I developed to help people like you who are dealing with histamine intolerance and related health issues, including PCOS. It is a simple yet refined system, so it is critical that you understand and follow each step properly. 

To understand each step and guide your recovery, I recommend that you read my book, The 4-Phase Histamine Reset Plan: Getting to the Root of Migraines, Eczema, Vertigo, Allergies and More where I explain everything about histamine intolerance and each phase of the plan in detail and share delicious low-histamine recipes to nourish your body and support your health. Pick up a copy, today to learn more about the plan and my recommendations.

Support Your Liver and Hormone Levels

Supporting your hormone levels is critical for improving your symptoms. This is why I recommend Optimal Reset Liver Love. This supplement is a powerful blend of botanical and mushroom extracts and N-Acetyl-L-Cysteine (NAC), a derivative of the amino acid cysteine. It supports healthy liver function, allows optimal estrogen detoxification, and supports your hormonal health naturally.

Reduce Histamine Intolerance

To improve histamine intolerance, I recommend HistoRelief, a synergistic blend of nutrients that provides natural support to balance your immune response. This supplement includes Tinofend®, a patented and clinically researched extract derived from the plant Tinospora cordifolia, which is used for its powerful ability to support immune regulation and immune response. It also features quercetin, nettle leaf, vitamin C, and bicarbonate salts. Quercetin is a fantastic bioflavonoid with anti-inflammatory and antioxidant properties that naturally inhibits histamine release. Research has shown that supplementing with quercetin may improve hormonal issues and may benefit those with PCOS. Bicarbonate salts may help to maintain normal histamine metabolism, while nettle leaf may help with hair loss and other hormonal issues, and vitamin C may suppress ovarian issues in PCOS (8, 9, 10, 11).

Support Ovarian Function

One of my favorite supplements I regularly recommend to my patients with PCOS is Ovasitol. It is an inositol supplement that supports normal hormone levels, healthy ovarian function, healthy egg quality, menstrual regularity, and insulin sensitivity. 

Final Thoughts

PCOS is a common hormonal issue in women. If you are someone with PCOS, you don’t have to support the statistics anymore. Follow my tips to reduce your symptoms of PCOS and to reclaim your health and happiness naturally.

If you are dealing with PCOS or histamine intolerance, I invite you to schedule a consultation with us. I can help to identify the root cause of your condition and recommend a personalized treatment plan to repair your body and regain your health and well-being. Schedule your consultation here.



1. PCOS (Polycystic Ovary Syndrome) and Diabetes. Centers for Disease Control and Prevention. Link Here
2. Polycystic Ovary Syndrome (PCOS). Hormone Health Network. Link Here
3. Polycystic ovary syndrome. US Department of Health and Human Services. Office of Women’s Health. Link Here
4. Polycystic Ovary Syndrome. Mayo Clinic. Link Here
5. Polycystic ovary Syndrome. Johns Hopkins Medicine. Link Here
6. Maintz L, Novak N, Histamine and histamine intolerance, The American Journal of Clinical Nutrition, Volume 85, Issue 5, May 2007, Pages 1185–1196. Link Here
7. Arduc A, Aycicek Dogan B, Bilmez S Imga Nasirouglu N, Tuna MM, Isik S, Berker D, Guler S. High prevalence of Hashimoto’s thyroiditis in patients with polycystic ovary syndrome: does the imbalance between estradiol and progesterone play a role? Endocrine Research. 2015;40(4):204-210. PMID: 25822940
8. Histamine intolerance. Vickerstaff Health Services. Link Here
9. Yang K., Zeng L., Bao T. et al. Exploring the pharmacological mechanism of quercetin-resveratrol combination for polycystic ovary syndrome: A Systematic Pharmacological Strategy-Based Research. Sci Rep 9, 18420 (2019). Link Here
10. Olanyan OT. Vitamin C suppresses ovarian pathophysiology in experimental polycystic ovarian syndrome. Pathophysiology. 2019 Sep – Dec;26(3-4):331-341. PMID: 31564389 
11. Stinging nettle is a powerful plant for PCOS. PCOS. Link Here





Hi, I am Dr. Becky Campbell. I work with men and women who’ve had a health set back and are willing to do whatever it takes to reach optimal health so they can perform their best in their careers and be fully present with their family again.

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